This actually occurred back on Thursday, January 3rd, but got lost in the shuffle.
Arizona hosted Oregon State in a Pac-10 Women's Basketball matchup. Due to two injuries, one academic ineligibility and one player out for personal reasons, Arizona only dressed six players. With 1:28 left in regulation, Arizona had a second player foul out, leaving them with only four players on the floor. They lost their lead, once 16 points, and went to overtime.
The NCAA and Title IX are considering banning men from serving as practice foes for women
With four players, Arizona actually stayed with Oregon State and forced a second OT. The wheels came off then. At the 2:28 mark another player fouled out. At the 1:01 mark, a fourth player fouled out, leaving Arizona to defend the court with only two players.
Obviously, 5-on-2 is a bit of a handicap. Arizona succumbed 94-88.
Imagine how bad this would have gotten in a men's game? What would the strategy be? Hold the ball for 35 seconds (and trying to avoid the 5-second violation) and then tossing up a highly contested three. The other team would then inbound and then run down and dunk. It would not have been pretty.